A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives

J Reed, S Bain, V Kanamarlapudi - Diabetes, Metabolic Syndrome …, 2021 - Taylor & Francis
Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …

High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms

CY Lian, ZZ Zhai, ZF Li, L Wang - Chemico-biological interactions, 2020 - Elsevier
Obesity is characterized by the deposition of excessive body fat, and is caused by energy
imbalance, especially when consuming fat-rich diets. High fat diet (HFD)-associated obesity …

Titanium for orthopedic applications: an overview of surface modification to improve biocompatibility and prevent bacterial biofilm formation

J Quinn, R McFadden, CW Chan, L Carson - IScience, 2020 - cell.com
Titanium and its alloys have emerged as excellent candidates for use as orthopedic
biomaterials. Nevertheless, there are often complications arising after implantation of …

Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality

LM Frydrych, G Bian, DE O'Lone… - Journal of leukocyte …, 2018 - academic.oup.com
Obesity and type 2 diabetes mellitus (T2D) are global pandemics. Worldwide, the
prevalence of obesity has nearly tripled since 1975 and the prevalence of T2D has almost …

Emerging role of SGLT-2 inhibitors for the treatment of obesity

MJ Pereira, JW Eriksson - Drugs, 2019 - Springer
Abstract Sodium-glucose co-transporter 2 (SGLT2) inhibitors are glucose-lowering drugs
that reduce plasma glucose levels by inhibiting glucose and sodium reabsorption in the …

Fructose consumption, lipogenesis, and non-alcoholic fatty liver disease

KW Ter Horst, MJ Serlie - Nutrients, 2017 - mdpi.com
Increased fructose consumption has been suggested to contribute to non-alcoholic fatty liver
disease (NAFLD), dyslipidemia, and insulin resistance, but a causal role of fructose in these …

Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue

SN Saxton, BJ Clark, SB Withers… - Physiological …, 2019 - journals.physiology.org
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Prevalence and trends in obesity among US adults, 1999-2008

KM Flegal, MD Carroll, CL Ogden, LR Curtin - Jama, 2010 - jamanetwork.com
Context The prevalence of obesity increased in the United States between 1976-1980 and
1988-1994 and again between 1988-1994 and 1999-2000. Objective To examine trends in …

Microglia play an active role in obesity-associated cognitive decline

EC Cope, EA LaMarca, PK Monari… - Journal of …, 2018 - Soc Neuroscience
Obesity affects> 600 million people worldwide, a staggering number that appears to be on
the rise. One of the lesser known consequences of obesity is its deleterious effects on …

Wearable sensor/device (Fitbit One) and SMS text-messaging prompts to increase physical activity in overweight and obese adults: a randomized controlled trial

B WangJulie, A Cadmus-BertramLisa… - Telemedicine and e …, 2015 - liebertpub.com
Background: Studies have shown self-monitoring can modify health behaviors, including
physical activity (PA). This study tested the utility of a wearable sensor/device (Fitbit® One™; …