Double‐strand breaks (DSBs) are the most detrimental DNA damage encountered by
bacterial cells. DBSs can be repaired by homologous recombination thanks to the …

To bypass a diverse range of fork stalling impediments encountered during genome
replication, cells possess a variety of DNA damage tolerance (DDT) mechanisms including …

During the initiation of DNA replication, oligonucleotide primers are synthesized de novo by
primases and are subsequently extended by replicative polymerases to complete genome …

The genomic integrity of Mycobacterium tuberculosis is continuously threatened by the
harsh survival conditions inside host macrophages, due to immune and antibiotic stresses …

Mycobacteria exploit at least two independent global systems in response to DNA damage:
the LexA/RecA-dependent SOS response and the PafBC-regulated pathway. Intracellular …

DNA ligases are diverse enzymes with essential functions in replication and repair of DNA;
here we review recent advances in their structure and distribution and discuss how this …

To pass on genetic information to the next generation, cells must faithfully replicate their
genomes to provide copies for each daughter cell. To synthesise these duplicates, cells …

The use of conventional antibiotic therapies is in question owing to the emergence of drug-
resistant pathogenic bacteria. Therefore, novel, highly efficient antibacterial agents to …

DNA ligases operating at low temperatures have potential advantages for use in
biotechnological applications. For this reason, we have characterized the temperature …

CRISPR-Cas pathways provide prokaryotes with acquired “immunity” against foreign
genetic elements, including phages and plasmids. Although many of the proteins associated …