For several decades, the reactive gliosis that occurs after an injury to the CNS has been
considered one of the major impediments to axonal regeneration. Nevertheless, recent …

Reactive astrogliosis is a pathologic hallmark of spinal cord injury (SCI). It is characterised
by profound morphological, molecular, and functional changes in astrocytes that occur …

Poor functional recovery after peripheral nerve injury has been generally attributed to
inability of denervated muscles to accept reinnervation and recover from denervation …

Most neurons of the mammalian central nervous system (CNS) lose the ability to regenerate
severed axons in vivo after a certain point in development1. At least part of this loss in …

In this study we evaluate the expression of all members of the class 3 semaphorins and their
receptor components following complete transection and contusion lesions of the adult rat …

The ability of peripheral nervous system (PNS) but not central nervous system (CNS)
neurons to regenerate their axons is a striking peculiarity of higher vertebrates. Much …

Scar formation represents a reaction of nervous tissue to any form of physical injury.
Research over the past decade has demonstrated that the scar composed of glial cells and …

Cell-to-cell communication during development and plasticity is controlled to a large extent
by signaling events downstream of receptor tyrosine kinases (RTKs). Most RTKs bind …

The movement disorder in Parkinson's disease results from the selective degeneration of a
small group of dopaminergic neurons in the substantia nigra pars compacta region of the …

The hyaluronic acid (HA) hydrogels modified with laminin were used for implantation in rat
brain in present study, in order to investigate its effects in reparation of injury in the CNS …