Many biological processes result from the effect of mechanical forces on macromolecular
structures and on their interactions. In particular, the cell shape, motion, and differentiation …

Adhesive molecular bonds between blood cells are essential for thrombosis and hemostasis
as they provide means for platelet adhesion, aggregation, and signaling in flowing blood …

Von Willebrand factor (VWF) activates in response to shear flow to initiate hemostasis, while
aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of …

Force-dependent binding of platelet glycoprotein Ib (GPIb) receptors to plasma von
Willebrand factor (VWF) plays a key role in hemostasis and thrombosis. Previous studies …

Neutrophils release their intracellular content, DNA included, into the bloodstream to form
neutrophil extracellular traps (NETs) that confine and kill circulating pathogens. The …

Von Willebrand factor (VWF), a large multimeric blood protein, senses changes in shear
stress during bleeding and responds by binding platelets to plug ruptures in the vessel wall …

The von Willebrand factor (VWF), by interacting with the circulatory system and platelets,
harnesses hemodynamic forces to form hemostatic plugs or occlusive thrombi. The …

Linking of sensor molecules (eg, antibodies) to an AFM tip converts it into a biosensor by
which single target molecules (eg, antigens) can be detected and localized on the sample …

The globular-to-unraveled conformation transition of von Willebrand factor (vWF), a large
polymeric glycoprotein in human blood plasma, is a crucial step in the process of clotting at …

von Willebrand factor (VWF) is a huge multimeric protein that plays a key role in primary
hemostasis. Sites for collagen binding, an initial event of hemostasis, are located in the VWF …