The rapid development of sequencing methods over the past decades has accelerated both
the potential scope and depth of microbiota and microbiome studies. Recent developments …

Expansions of short tandem repeats are genetic variants that have been implicated in
several neuropsychiatric and other disorders, but their assessment remains challenging with …

Mammalian cells stably maintain high levels of DNA methylation despite expressing both
positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent …

DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and
operate within distinct genomic compartments. In mammals, the majority of the genome is …

Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various
biological processes, including embryonic development and cellular differentiation. Despite …

Methylation microarray and bisulphite sequencing are often used to study 5'-methylcytosine
(5'-mC) modification of CpG dinucleotides in the human genome. Although both …

Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various
biological processes, including embryonic development and cellular differentiation. Despite …

Background Once aligned, long-reads can be a useful source of information to identify the
type and position of structural variations. However, due to the high sequencing error of long …

Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various
biological processes, including embryonic development and cellular differentiation. Despite …

The assembly of reference-quality, chromosome-level genomes for both model and novel
eukaryotic organisms is an increasingly achievable task for single research teams. However …