Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Background & Aims Renewal and patterning of the intestinal epithelium is coordinated by
intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that …

This article provides an initial assessment of the many risks posed by the COVID-19
pandemic on the conduct of genuine and transparent elections in the world. It begins with …

The G-protein-coupled bile acid receptor (GPBAR) conveys the cross-membrane signalling
of a vast variety of bile acids and is a signalling hub in the liver–bile acid–microbiota …

Cytosolic DNA is an indicator of pathogen invasion or DNA damage. The cytosolic DNA
sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase …

Bile acids (BAs) as cholesterol-derived molecules play an essential role in some
physiological processes such as nutrient absorption, glucose homeostasis and regulation of …

The interferon (IFN) response is the major early innate immune response against invading
viral pathogens and is even capable of mediating sterilizing antiviral immunity without the …

STING (stimulator of interferon genes) exerts protective cellular responses to viral infection
via induction of interferon production and autophagy. Here, we report the role of STING in …

Fever is a common symptom of influenza and coronavirus disease 2019 (COVID-19), yet its
physiological role in host resistance to viral infection remains less clear. Here, we …