IL-6 and IL-8: an overview of their roles in healthy and pathological pregnancies

A Vilotić, M Nacka-Aleksić, A Pirković… - International journal of …, 2022 - mdpi.com
Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

Comprehensive analysis of COVID-19 during pregnancy

KM Moore, MS Suthar - Biochemical and biophysical research …, 2021 - Elsevier
The COVID-19 pandemic resulting from the emergence of the coronavirus SARS-CoV-2
remains a major global health concern. Pregnant individuals are more likely to develop …

The role of inflammation in the pathology of preeclampsia

AC Harmon, DC Cornelius, LM Amaral… - Clinical …, 2016 - portlandpress.com
Preeclampsia (PE) affects 5–7% of all pregnancies in the United States and is the leading
cause of maternal and prenatal morbidity. PE is associated with hypertension after week 20 …

Matrix metalloproteinases in normal pregnancy and preeclampsia

J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia

H Qu, RA Khalil - American Journal of Physiology-Heart and …, 2020 - journals.physiology.org
Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …

Mechanisms of endothelial dysfunction in hypertensive pregnancy and preeclampsia

JS Possomato-Vieira, RA Khalil - Advances in pharmacology, 2016 - Elsevier
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead
to maternal and fetal morbidity and mortality. Although the causative factors and …

Interleukin-6 in pregnancy and gestational disorders

JR Prins, N Gomez-Lopez, SA Robertson - Journal of reproductive …, 2012 - Elsevier
IL6 is a multifunctional cytokine with pivotal roles in the inflammatory response and in
directing T cell differentiation in adaptive immunity. IL6 is widely expressed in the female …

Activation of the maternal immune system induces endocrine changes in the placenta via IL-6

EY Hsiao, PH Patterson - Brain, behavior, and immunity, 2011 - Elsevier
Activation of the maternal immune system in rodent models sets in motion a cascade of
molecular pathways that ultimately result in autism-and schizophrenia-related behaviors in …

[HTML][HTML] Cytokines as key players in the pathophysiology of preeclampsia

R Raghupathy - Medical Principles and Practice, 2013 - karger.com
Preeclampsia (PE) is an important, common, and dangerous complication of pregnancy; it
causes maternal and perinatal illness and is responsible for a high proportion of maternal …

Neurodevelopmental outcomes of prenatal preeclampsia exposure

SB Gumusoglu, ASS Chilukuri, DA Santillan… - Trends in …, 2020 - cell.com
Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to
negative child health outcomes. Here, we review epidemiological and basic neuroscience …