[PDF][PDF] Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …
Natural and synthetic compounds in Ovarian Cancer: A focus on NRF2/KEAP1 pathway
G Tossetta, D Marzioni - Pharmacological Research, 2022 - Elsevier
Among gynecologic malignancies, ovarian cancer is one of the most dangerous, with a high
fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …
fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …
Epidermal growth factor receptor targeting in cancer: a review of trends and strategies
The epidermal growth factor receptor (EGFR) is a cell-surface receptor belonging to ErbB
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …
Structure and dynamics of the EGFR/HER2 heterodimer
X Bai, P Sun, X Wang, C Long, S Liao, S Dang… - Cell Discovery, 2023 - nature.com
HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family. Its
overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 …
overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 …
The yin and yang of ERBB4: tumor suppressor and oncoprotein
Abstract ERBB4 (HER4) is a member of the ERBB family of receptor tyrosine kinases, a
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …
EGFR amplification and lack of activating mutations in metaplastic breast carcinomas
JS Reis‐Filho, C Pinheiro… - The Journal of …, 2006 - Wiley Online Library
Metaplastic breast carcinomas are reported to harbour epidermal growth factor receptor
(EGFR) overexpression in up to 80% of the cases, but EGFR gene amplification is the …
(EGFR) overexpression in up to 80% of the cases, but EGFR gene amplification is the …
[HTML][HTML] Efficacy and mechanism of action of the tyrosine kinase inhibitors gefitinib, lapatinib and neratinib in the treatment of HER2-positive breast cancer: preclinical …
M Segovia-Mendoza… - American journal of …, 2015 - ncbi.nlm.nih.gov
An increasing number of tumors, including breast cancer, overexpress proteins of the
epidermal growth factor receptor (EGFR) family. The interaction between family members …
epidermal growth factor receptor (EGFR) family. The interaction between family members …
Comparative study on overexpression of HER2/neu and HER3 in gastric cancer
XL Zhang, YS Yang, DP Xu, JH Qu, MZ Guo… - World journal of …, 2009 - Springer
Background Owing to the special importance of the HER family in tumorigenesis, the
downstream signaling pathways and effectors have become the key molecules in the …
downstream signaling pathways and effectors have become the key molecules in the …
Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance
Background In breast cancer, overexpression of the transmembrane tyrosine kinase ERBB2
is an adverse prognostic marker, and occurs in almost 30% of the patients. For therapeutic …
is an adverse prognostic marker, and occurs in almost 30% of the patients. For therapeutic …
EGFR signaling in breast cancer: bad to the bone
J Foley, NK Nickerson, S Nam, KT Allen… - Seminars in cell & …, 2010 - Elsevier
The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor
tyrosine kinases. This family includes EGFR/ErbB1/HER1, ErbB2/HER2/Neu ErbB3/HER3 …
tyrosine kinases. This family includes EGFR/ErbB1/HER1, ErbB2/HER2/Neu ErbB3/HER3 …