Exploring the expanding universe of small RNAs

J Shi, T Zhou, Q Chen - Nature cell biology, 2022 - nature.com
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …

Noncanonical roles of tRNAs: tRNA fragments and beyond

Z Su, B Wilson, P Kumar, A Dutta - Annual review of genetics, 2020 - annualreviews.org
As one of the most abundant and conserved RNA species, transfer RNAs (tRNAs) are well
known for their role in reading the codons on messenger RNAs and translating them into …

PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

J Shi, Y Zhang, D Tan, X Zhang, M Yan, Y Zhang… - Nature cell …, 2021 - nature.com
Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-
coding RNA (sncRNA) discovery, the currently widely used complementary DNA library …

Roles and regulation of tRNA-derived small RNAs in animals

S Muthukumar, CT Li, RJ Liu, C Bellodi - Nature Reviews Molecular Cell …, 2024 - nature.com
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …

Sperm RNA code programmes the metabolic health of offspring

Y Zhang, J Shi, M Rassoulzadegan, F Tuorto… - Nature Reviews …, 2019 - nature.com
Mammalian sperm RNA is increasingly recognized as an additional source of paternal
hereditary information beyond DNA. Environmental inputs, including an unhealthy diet …

Deciphering the tRNA-derived small RNAs: origin, development, and future

B Liu, J Cao, X Wang, C Guo, Y Liu, T Wang - Cell Death & Disease, 2021 - nature.com
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding
RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the …

Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs

Y Zhang, L Ren, X Sun, Z Zhang, J Liu, Y Xin… - Nature …, 2021 - nature.com
Paternal environmental inputs can influence various phenotypes in offspring, presenting
tremendous implications for basic biology and public health and policy. However, which …

tRNA renovatio: rebirth through fragmentation

B Kuhle, Q Chen, P Schimmel - Molecular Cell, 2023 - cell.com
Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …

Soma-to-germline RNA communication

CC Conine, OJ Rando - Nature Reviews Genetics, 2022 - nature.com
More than a century ago, August Weissman defined a distinction between the germline
(responsible for propagating heritable information from generation to generation) and the …

Human sperm displays rapid responses to diet

D Nätt, U Kugelberg, E Casas, E Nedstrand… - PLoS …, 2019 - journals.plos.org
The global rise in obesity and steady decline in sperm quality are two alarming trends that
have emerged during recent decades. In parallel, evidence from model organisms shows …