Adaptations and metabolic evolution of myzozoan protists across diverse lifestyles and environments

RF Waller, VB Carruthers - Microbiology and Molecular Biology …, 2024 - journals.asm.org
Myzozoans encompass apicomplexans and dinoflagellates that manifest diverse lifestyles in
highly varied environments. They show enormous propensity to employ different metabolic …

The Toxoplasma plant‐like vacuolar compartment (PLVAC)

AJ Stasic, SNJ Moreno… - Journal of Eukaryotic …, 2022 - Wiley Online Library
Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of
congenital disease and infection in immunocompromised patients. T. gondii shares several …

The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondii

D Aghabi, M Sloan, G Gill, E Hartmann… - Nature …, 2023 - nature.com
Iron is essential to cells as a cofactor in enzymes of respiration and replication, however
without correct storage, iron leads to the formation of dangerous oxygen radicals. In yeast …

An uninvited seat at the dinner table: how apicomplexan parasites scavenge nutrients from the host

F Piro, R Focaia, Z Dou, S Masci, D Smith, M Di Cristina - Microorganisms, 2021 - mdpi.com
Obligate intracellular parasites have evolved a remarkable assortment of strategies to
scavenge nutrients from the host cells they parasitize. Most apicomplexans form a …

A key cytosolic iron–sulfur cluster synthesis protein localizes to the mitochondrion of Toxoplasma gondii

YTV Aw, A Seidi, JA Hayward, J Lee… - Molecular …, 2021 - Wiley Online Library
Abstract Iron–sulfur (Fe‐S) clusters are prosthetic groups on proteins that function in a range
of enzymatic and electron transfer reactions. Fe‐S cluster synthesis is essential for the …

Non-Enzymatic Synthesis of Bioactive Isoprostanoids in the Diatom Phaeodactylum following Oxidative Stress

J Lupette, A Jaussaud, C Vigor, C Oger… - Plant …, 2018 - academic.oup.com
The ecological success of diatoms requires a remarkable ability to survive many types of
stress, including variations in temperature, light, salinity, and nutrient availability. On …

An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in …

LB Thornton, P Teehan, K Floyd, C Cochrane… - PLoS …, 2019 - journals.plos.org
Toxoplasma gondii is an apicomplexan parasite with the ability to use foodborne, zoonotic,
and congenital routes of transmission that causes severe disease in immunocompromised …

A novel ENTH domain-containing protein TgTEPSIN is essential for structural maintenance of the plant-like vacuolar compartment and bradyzoite differentiation in …

K He, R Wu, A Yan, X Liu, S Long - International Journal of Biological …, 2025 - Elsevier
Toxoplasma gondii is an intracellular and parasitic protozoon that harbors specialized
cellular structures and molecular mechanisms, including the Plant-like Vacuolar …

Toxoplasma gondii autophagy‐related protein ATG9 is crucial for the survival of parasites in their host

HM Nguyen, H El Hajj, R El Hajj, N Tawil… - Cellular …, 2017 - Wiley Online Library
Autophagy is a conserved, life‐promoting, catabolic process involved in the recycling of
nonessential cellular components in response to stress. The parasite Toxoplasma gondii is …

A single Na+-Pi cotransporter in Toxoplasma plays key roles in phosphate import and control of parasite osmoregulation

B Asady, CF Dick, K Ehrenman, T Sahu… - PLoS …, 2020 - journals.plos.org
Inorganic ions such as phosphate, are essential nutrients required for a broad spectrum of
cellular functions and regulation. During infection, pathogens must obtain inorganic …