Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …

Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related
diseases, including hematologic malignancy and atherosclerotic cardiovascular disease …

Systemic inflammatory and autoimmune diseases and myelodysplastic syndromes have
been linked in individual patients and in larger case series for at least 25 years. These …

Abstract Background The Inspiration4 (I4) mission, the first all-civilian orbital flight mission,
investigated the physiological effects of short-duration spaceflight through a multi-omic …

Over the past few years, we have gained a deeper understanding of clonal hematopoiesis of
indeterminate potential (CHIP), especially with regard to the epidemiology, clinical …

Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …

Exposure to cancer therapies is associated with an increased risk of clonal hematopoiesis
(CH). The objective of our study was to investigate the genesis and evolution of CH after …

Clonal hematopoiesis (CH) is defined by the presence of somatic mutations in
hematopoietic stem and progenitor cells (HSPC). CH is associated primarily with advancing …

With age, acquired mutations can cause clonal expansion of hematopoietic stem cells
(HSC). This clonal hematopoiesis of indeterminate potential (CHIP) leads to an increased …