Biofilms: Survival and defense strategy for pathogens
Studies on biofilm related infections are gaining prominence owing to their involvement in
majority of clinical infections. Biofilm, considered as a generic mechanism for survival used …
majority of clinical infections. Biofilm, considered as a generic mechanism for survival used …
Regulation of mRNA stability during bacterial stress responses
DA Vargas-Blanco, SS Shell - Frontiers in microbiology, 2020 - frontiersin.org
Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their
transcriptional and posttranscriptional machinery as a response. Under conditions that …
transcriptional and posttranscriptional machinery as a response. Under conditions that …
Cryo-EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH
Ribosome hibernation is a key survival strategy bacteria adopt under environmental stress,
where a protein, hibernation promotion factor (HPF), transitorily inactivates the ribosome …
where a protein, hibernation promotion factor (HPF), transitorily inactivates the ribosome …
An obligately aerobic soil bacterium activates fermentative hydrogen production to survive reductive stress during hypoxia
M Berney, C Greening, R Conrad… - Proceedings of the …, 2014 - National Acad Sciences
Oxygen availability is a major factor and evolutionary force determining the metabolic
strategy of bacteria colonizing an environmental niche. In the soil, conditions can switch …
strategy of bacteria colonizing an environmental niche. In the soil, conditions can switch …
Investigating function roles of hypothetical proteins encoded by the Mycobacterium tuberculosis H37Rv genome
Background Mycobacterium tuberculosis (MTB) is a common bacterium causing
tuberculosis and remains a major pathogen for mortality. Although the MTB genome has …
tuberculosis and remains a major pathogen for mortality. Although the MTB genome has …
Global adaptation to a lipid environment triggers the dormancy-related phenotype of Mycobacterium tuberculosis
JG Rodríguez, AC Hernández, C Helguera-Repetto… - MBio, 2014 - Am Soc Microbiol
Strong evidence supports the idea that fatty acids rather than carbohydrates are the main
energy source of Mycobacterium tuberculosis during infection and latency. Despite that …
energy source of Mycobacterium tuberculosis during infection and latency. Despite that …
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis
Abstract Ribosomes from Mycobacterium tuberculosis (Mtb) possess species-specific
ribosomal RNA (rRNA) expansion segments and ribosomal proteins (rProtein). Here, we …
ribosomal RNA (rRNA) expansion segments and ribosomal proteins (rProtein). Here, we …
The complete structure of the Mycobacterium smegmatis 70S ribosome
J Hentschel, C Burnside, I Mignot, M Leibundgut… - Cell reports, 2017 - cell.com
The ribosome carries out the synthesis of proteins in every living cell. It consequently
represents a frontline target in anti-microbial therapy. Tuberculosis ranks among the leading …
represents a frontline target in anti-microbial therapy. Tuberculosis ranks among the leading …
Tuberculosis challenges: Resistance, co-infection, diagnosis, and treatment
Early diagnosis of tuberculosis (TB), followed by effective treatment, is the cornerstone of
global TB control efforts. An estimated 3 million cases of TB remain undetected each year …
global TB control efforts. An estimated 3 million cases of TB remain undetected each year …
Structure of ribosomal silencing factor bound to Mycobacterium tuberculosis ribosome
The ribosomal silencing factor RsfS slows cell growth by inhibiting protein synthesis during
periods of diminished nutrient availability. The crystal structure of Mycobacterium …
periods of diminished nutrient availability. The crystal structure of Mycobacterium …