Disinhibition, a circuit mechanism for associative learning and memory
JJ Letzkus, SBE Wolff, A Lüthi - Neuron, 2015 - cell.com
Although a wealth of data have elucidated the structure and physiology of neuronal circuits,
we still only have a very limited understanding of how behavioral learning is implemented at …
we still only have a very limited understanding of how behavioral learning is implemented at …
Direction selectivity in the retina: symmetry and asymmetry in structure and function
Visual information is processed in the retina to a remarkable degree before it is transmitted
to higher visual centres. Several types of retinal ganglion cells (the output neurons of the …
to higher visual centres. Several types of retinal ganglion cells (the output neurons of the …
[HTML][HTML] Reconstruction and simulation of neocortical microcircuitry
We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …
Discrete attractor dynamics underlies persistent activity in the frontal cortex
Short-term memories link events separated in time, such as past sensation and future
actions. Short-term memories are correlated with slow neural dynamics, including selective …
actions. Short-term memories are correlated with slow neural dynamics, including selective …
Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons
Cortical inhibitory neurons contact each other to form a network of inhibitory synaptic
connections. Our knowledge of the connectivity pattern underlying this inhibitory network is …
connections. Our knowledge of the connectivity pattern underlying this inhibitory network is …
Cortical somatostatin interneuron subtypes form cell-type-specific circuits
The cardinal classes are a useful simplification of cortical interneuron diversity, but such
broad subgroupings gloss over the molecular, morphological, and circuit specificity of …
broad subgroupings gloss over the molecular, morphological, and circuit specificity of …
[HTML][HTML] Enhanced dendritic compartmentalization in human cortical neurons
L Beaulieu-Laroche, EHS Toloza, MS Van der Goes… - Cell, 2018 - cell.com
The biophysical features of neurons shape information processing in the brain. Cortical
neurons are larger in humans than in other species, but it is unclear how their size affects …
neurons are larger in humans than in other species, but it is unclear how their size affects …
Principles of connectivity among morphologically defined cell types in adult neocortex
INTRODUCTION The intricate microcircuitry of the cerebral cortex is thought to be a critical
substrate from which arise the impressive capabilities of the mammalian brain. Until now …
substrate from which arise the impressive capabilities of the mammalian brain. Until now …
Inhibition dominates sensory responses in the awake cortex
The activity of the cerebral cortex is thought to depend on the precise relationship between
synaptic excitation and inhibition,,,. In the visual cortex, in particular, intracellular …
synaptic excitation and inhibition,,,. In the visual cortex, in particular, intracellular …
The autism-associated gene Scn2a contributes to dendritic excitability and synaptic function in the prefrontal cortex
Autism spectrum disorder (ASD) is strongly associated with de novo gene mutations. One of
the most commonly affected genes is SCN2A. ASD-associated SCN2A mutations impair the …
the most commonly affected genes is SCN2A. ASD-associated SCN2A mutations impair the …