Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …

Esophageal cancer (EC) is a disease often marked by aggressive growth and poor
prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant …

The increase in available high-throughput molecular data creates computational challenges
for the identification of cancer genes. Genetic as well as non-genetic causes contribute to …

Metastatic cancer cells are lethal. Understanding the molecular mechanisms that bolster the
conversion from benign to malignant progression is key for treating these heterogeneous …

Metabolic reprogramming is one of the main characteristics of malignant tumors. The
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …

The epithelial to mesenchymal transition (EMT) is an important step for the developmental
process. Recent evidences support that EMT allows the tumor cells to acquire invasive …

Twist1 is a well-known regulator of transcription during embryonic organogenesis in many
species. In humans, Twist1 malfunction was first linked to Saethre-Chotzen syndrome and …

Muscle stem cell (satellite cell) activation post muscle injury is a transient and critical step in
muscle regeneration. It is regulated by physiological cues, signaling molecules, and …

Until now detection and numeration of circulating tumor cells (CTCs) were essentially used
as a prognostic factor in cancer progression. To extend the role of these kinds of analysis, it …

Apico-basal polarity is typical of cells present in differentiated epithelium while front-rear
polarity develops in motile cells. In cancer development, the transition from epithelial to …