ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as
nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives …

The paper discusses the techniques which are currently implemented for vaccine production
based on virus-like particles (VLPs). The factors which determine the characteristics of VLP …

Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR)
causes genomic instability. Genomic instability occurs in Wiskott-Aldrich syndrome (WAS), a …

Immunoactinopathies caused by mutations in actin‐related proteins are a growing group of
inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin …

The nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of
hepatocellular carcinoma (HCC). Phosphorylation of p65 is considered as an important …

Reversion mosaicism has been reported in an increasing number of genetic disorders
including primary immunodeficiency diseases. Several mechanisms can mediate somatic …

Small ubiquitin-like modifier (SUMO) proteins belong to the ubiquitin-like family and act to
change the function of target proteins through post-translational modifications. Through their …

ABSTRACT The COMMD Protein Family is highly conserved among multicellular eukaryotic
organisms and many orthologs of human COMMD genes have been found in different …

Protein SUMOylation has been reported to play a role in innate immune response, but the
enzymes, substrates, and consequences of the specific inflammatory signaling events are …

The RTS, S candidate malaria vaccine can protect against controlled human malaria
infection (CHMI), but how protection is achieved remains unclear. Here, we have analyzed …