Quantitative analysis of multiphoton excitation autofluorescence and second harmonic generation imaging for medical diagnosis

WL Chen, PS Hu, A Ghazaryan, SJ Chen… - … Medical Imaging and …, 2012 - Elsevier
In recent years, two-photon excitation fluorescence and second harmonic generation
microscopy has become an important tool in biomedical research. The ability of two-photon …

Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation

TL Lynch IV, M Sivaguru, M Velayutham… - Oxidative medicine …, 2015 - Wiley Online Library
Cardiomyopathies can result from mutations in genes encoding sarcomere proteins
including MYBPC3, which encodes cardiac myosin binding protein‐C (cMyBP‐C). However …

Cardiac atrial appendage stem cells engraft and differentiate into cardiomyocytes in vivo: A new tool for cardiac repair after MI

Y Fanton, B Robic, JL Rummens, A Daniëls… - International journal of …, 2015 - Elsevier
Background This study assessed whether autologous transplantation of cardiac atrial
appendage stem cells (CASCs) preserves cardiac function after myocardial infarction (MI) in …

Imaging of biological tissues with pixel-level analysis of second-order susceptibility

PS Hu, A Ghazaryan, V Hovhannisyan… - … of biomedical optics, 2013 - spiedigitallibrary.org
We discuss the recent advances in the development and applications of second-order
susceptibility as a contrast mechanism in optical microscopy for biological tissues. We …

Theoretical and experimental SHG angular intensity patterns from healthy and proteolysed muscles

D Rouède, JJ Bellanger, E Schaub, G Recher… - Biophysical journal, 2013 - cell.com
SHG angular intensity pattern (SHG-AIP) of healthy and proteolysed muscle tissues are
simulated and imaged here for the first time to our knowledge. The role of the spatial …

Determination of the source of SHG verniers in zebrafish skeletal muscle

WP Dempsey, NO Hodas, A Ponti, P Pantazis - Scientific reports, 2015 - nature.com
SHG microscopy is an emerging microscopic technique for medically relevant imaging
because certain endogenous proteins, such as muscle myosin lattices within muscle cells …

Myofibrillar misalignment correlated to triad disappearance of mdx mouse gastrocnemius muscle probed by SHG microscopy

D Rouède, P Coumailleau, E Schaub… - Biomedical optics …, 2014 - opg.optica.org
We show that the canonical single frequency sarcomeric SHG intensity pattern (SHG-IP) of
control muscles is converted to double frequency sarcomeric SHG-IP in preserved mdx …

Study of the effect of myofibrillar misalignment on the sarcomeric SHG intensity pattern

D Rouède, JJ Bellanger, G Recher, F Tiaho - Optics express, 2013 - opg.optica.org
We present a theoretical simulation of the sarcomeric SHG intensity pattern (SHG-IP) that
takes into account myofibrillar misalignment that is experimentally observed in SHG images …

Structural origin of the drastic modification of second harmonic generation intensity pattern occurring in tail muscles of climax stages xenopus tadpoles

G Recher, P Coumailleau, D Rouède… - Journal of Structural …, 2015 - Elsevier
Second harmonic generation (SHG) microscopy is a powerful tool for studying submicron
architecture of muscles tissues. Using this technique, we show that the canonical single …

Fully automated muscle quality assessment by Gabor filtering of second harmonic generation images

R Paesen, S Smolders, JMH Vega… - Journal of …, 2016 - spiedigitallibrary.org
Although structural changes on the sarcomere level of skeletal muscle are known to occur
due to various pathologies, rigorous studies of the reduced sarcomere quality remain …