Public health globally faces significant risks from conditions like acute respiratory distress
syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and various …

Fibrosis is universally observed in multiple aging-related diseases and progressions and is
characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various …

The inflammasome has an essential function in innate immune, responding to a wide variety
of stimuli. Here we show that the lncRNA Neat1 promotes the activation of several …

Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney
failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of …

Abstract Vitamin D/Vitamin D receptor (VDR) has been shown to inhibit the NF-κB-mediated
inflammatory effects. Up-regulation of the NLRP3 (Recombinant NLR Family, Pyrin Domain …

Inflammation is involved in pathogenesis of hypertension. NLRP3 inflammasome activation
is a powerful mediator of inflammatory response via caspase-1 activation. The present study …

Background Studying epigenetics is expected to provide precious information on how
environmental factors contribute to type 2 diabetes mellitus (T2DM) at the genomic level …

Neutrophil extracellular traps (NETs) that are produced in the tumour microenvironment
(TME) have been suggested to play an essential role in the dissemination of metastatic …

It is now increasingly appreciated that inflammation is not limited to the control of pathogens
by the host, but rather that sterile inflammation which occurs in the absence of viral or …

Diabetic nephropathy (DN), which is a common microvascular complication with a high
incidence in diabetic patients, greatly increases the mortality of patients. With further study …