RNA molecules can fold into intricate shapes that can provide an additional layer of control
of gene expression beyond that of their sequence. In this Review, we discuss the current …

Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA
granules that dynamically sequester translationally inactive messenger ribonucleoprotein …

Mammalian stress granules (SGs) contain stalled translation preinitiation complexes that are
assembled into discrete granules by specific RNA-binding proteins such as G3BP. We now …

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

The stereodivergent total synthesis of all stereoisomers of bioactive natural compounds to
enable complete evaluation of stereochemical structure-activity relationships is highly …

Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the
interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) …

The translational control of oncoprotein expression is implicated in many cancers. Here we
report an eIF4A RNA helicase-dependent mechanism of translational control that contributes …

Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …

Coronaviruses (CoV) and picornaviruses are plus-strand RNA viruses that use 5′ cap-
dependent and cap-independent strategies, respectively, for viral mRNA translation …

Abstract In BRAF (V600)-mutant tumours, most mechanisms of resistance to drugs that target
the BRAF and/or MEK kinases rely on reactivation of the RAS–RAF–MEK–ERK mitogen …