Immunosenescence: emerging challenges for an ageing population

D Aw, AB Silva, DB Palmer - Immunology, 2007 - Wiley Online Library
It is now becoming apparent that the immune system undergoes age‐associated alterations,
which accumulate to produce a progressive deterioration in the ability to respond to …

Insights into thymic aging and regeneration

DD Taub, DL Longo - Immunological reviews, 2005 - Wiley Online Library
The deterioration of the immune system with progressive aging is believed to contribute to
morbidity and mortality in elderly humans due to the increased incidence of infection …

Immunophenotyping of blood lymphocytes in childhoodReference values for lymphocyte subpopulations

WM Comans-Bitter, R de Groot, R van den Beemd… - The Journal of …, 1997 - Elsevier
Objective: Immunophenotyping of blood lymphocytes is an important tool in the diagnosis of
hematologic and immunologic disorders. Because of maturation and expansion of the …

Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)+ TH2/TH1 cell imbalance, whereas adults acquire CLA+ TH22/TC22 cell subsets

T Czarnowicki, H Esaki, J Gonzalez, D Malajian… - Journal of Allergy and …, 2015 - Elsevier
Background Identifying differences and similarities between cutaneous lymphocyte antigen
(CLA)+ polarized T-cell subsets in children versus adults with atopic dermatitis (AD) is …

Thymic involution in aging

R Aspinall, D Andrew - Journal of clinical immunology, 2000 - Springer
The size of the na¨ ıve T-cell pool is governed by output from the thymus and not by
replication. This pool contributes cells to the activated/memory T-cell pool whose size can be …

Reference values for peripheral blood lymphocyte phenotypes applicable to the healthy adult population in Switzerland

LR Bisset, TL Lung, M Kaelin… - European journal of …, 2004 - Wiley Online Library
Objectives: Use of domestic reference values is known to improve the accuracy of flow
cytometric analysis by integrating local variation due to race, gender, and age. In the …

Age‐and sex‐related changes in lymphocyte subpopulations of healthy Asian subjects: From birth to adulthood

BW Lee, HK Yap, FT Chew, TC Quah… - … : The Journal of the …, 1996 - Wiley Online Library
Flow cytometric analysis of lymphocyte subsets were evaluated in 391 healthy Asian
subjects ranging in age from birth to 40 years. Lymphocyte subsets were analysed using …

Lymphocytes subsets reference values in childhood

F Tosato, G Bucciol, G Pantano, MC Putti… - Cytometry Part …, 2015 - Wiley Online Library
Immunophenotyping of blood lymphocyte subsets and activation markers is a basic tool in
the diagnostic process of primary immunodeficiency diseases, its use becoming more and …

Species comparison of anatomical and functional immune system development

MP Holsapple, LJ West… - Birth Defects Research …, 2003 - Wiley Online Library
The components of the immune system have not been traditionally emphasized as potential
target organs in standard developmental and reproductive toxicity (DART) protocols. A …

When the damage is done: injury and repair in thymus function

S Kinsella, JA Dudakov - Frontiers in immunology, 2020 - frontiersin.org
Even though the thymus is exquisitely sensitive to acute insults like infection, shock, or
common cancer therapies such as cytoreductive chemo-or radiation-therapy, it also has a …