Epigenetics-targeted drugs: current paradigms and future challenges

W Dai, X Qiao, Y Fang, R Guo, P Bai, S Liu… - … and Targeted Therapy, 2024 - nature.com
Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Adverse effects of cadmium on lymphoid organs, immune cells, and immunological responses

P Kumari, KP Nanda, H Firdaus - Journal of Applied Toxicology, 2025 - Wiley Online Library
Humans and animals possess robust immune systems to safeguard against foreign
pathogens. However, recent reports suggest a greater incidence of immunity breakdown …

[HTML][HTML] Cadmium induced immunosuppression through TLR-IκBα-NFκB signaling by promoting autophagic degradation

J Gu, K Li, H Lin, Y Wang, Y Zhou, D Chen, X Gu… - Ecotoxicology and …, 2023 - Elsevier
Environmental and occupational exposure to cadmium (Cd) poses a serious threat to human
health. Recent studies indicate that Cd perturbs the immune system and increases the risk of …

[HTML][HTML] Cadmium promoted LPS-induced inflammation through TLR4/IκBα/NFκ-B signaling by increasing ROS-mediated incomplete autophagy

C Guo, J Ruan, Z Li, H Fu, K Li, X Gong, X Gu… - Ecotoxicology and …, 2024 - Elsevier
Cadmium (Cd) exposure is considered as non-infectious stressor to human and animal
health. Recent studies suggest that the immunotoxicity of low dose Cd is not directly …

[HTML][HTML] Anti-inflammatory effects of moxifloxacin and levofloxacin on cadmium-activated human astrocytes: Inhibition of proinflammatory cytokine release, TLR4 …

S Phuagkhaopong, J Sukwattanasombat, K Suknuntha… - PloS one, 2025 - journals.plos.org
Cadmium is a non-essential element and neurotoxin that causes neuroinflammation, which
leads to neurodegenerative diseases and brain cancer. To date, there are no specific or …

Tempol mitigates inflammation, oxidative stress, and histopathological alterations of cadmium-induced parotid gland injury in rats

SS Abd El-Fatah, OE Nafea, DM Yousef, W Samy… - Life Sciences, 2024 - Elsevier
Cadmium (Cd) is a potent environmental pollutant that causes functional and structural
damage to the salivary glands. Tempol (TEM) has powerful antioxidant activity that can …

Rutin Nanoparticles Alleviate Cadmium-Induced Oxidative and Immune Damage in Broilers' Bursa of Fabricius via Modulating Hsp70/TLR4/NF-κB Signaling Pathway

M Abomosallam, BM Hendam, Z Shouman… - … Trace Element Research, 2024 - Springer
Cadmium (Cd) is a serious environmental pollutant affecting various tissues/organs in
broilers and compromising their immunological function and productivity. Therefore, the …

Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway

M Savran, S Asci, K Gulle, R Aslankoc… - Toxicology …, 2024 - Taylor & Francis
Side effects of doxorubicin (DOX) are mainly due to oxidative stress, with the involvement of
inflammatory and apoptotic mechanisms. Agomelatine (AGO) is a melatonin receptor …

Increased serum levels of high-mobility group box 1 protein and the location characteristics in the patients of intracranial aneurysms

YX Lyu, HJ Tu, J Luo, CJ Wang, AR Li, Y Zhou… - Brain Research, 2024 - Elsevier
Objective Inflammation-related factors play a crucial role in intracranial aneurysms (IA)
initiation, progression, and rupture. High mobility group box 1 (HMGB-1) serves as an alarm …

Agomelatine protects hippocampal neurons against doxorubicin induced toxicity

B Danısman, B Cicek - GSC Biological and Pharmaceutical …, 2023 - gsconlinepress.com
Doxorubicin (DOX) is a powerful chemotherapy drug used in numerous cancer treatments,
known to causes neurotoxicity and impair cognitive function in cancer patients. The main …