While virtually absent in our diet a few hundred years ago, fructose has now become a major
constituent of our modern diet. Our main sources of fructose are sucrose from beet or cane …

Fructose consumption and its implications on public health are currently under study. This
work reviewed the metabolic fate of dietary fructose based on isotope tracer studies in …

Compared with other carbohydrates, fructose-containing caloric sweeteners (sucrose, high-
fructose corn syrup, pure fructose and fructose-glucose mixtures) are characterized by: a …

The liver is an important site of postprandial glucose disposal, accounting for the removal of
up to 30% of an oral glucose load. The liver is also centrally involved in dietary lipid and …

Sodium-glucose cotransporter type 2 (SGLT-2) inhibitors (canagliflozin, dapagliflozin,
empagliflozin) are new glucose-lowering agents that exert their therapeutic activity …

Background &aims Dietary sugars are absorbed in the hepatic portal circulation as glucose,
fructose, or galactose. The gut and liver are required to process fructose and galactose into …

Ingestion of pure fructose stimulates de novo lipogenesis and gluconeogenesis. This may
however not be relevant to typical nutritional situations, where fructose is invariably ingested …

Fructose metabolism is generally held to occur essentially in cells of the small bowel, the
liver, and the kidneys expressing fructolytic enzymes (fructokinase, aldolase B and a …

Introduction: Despite type 2 diabetes (T2D) being recognized as a bihormonal pancreatic
disease, current therapies are mainly focusing on insulin, while targeting glucagon has been …

Hepatic and extrahepatic insulin sensitivity was assessed in six healthy humans from the
insulin infusion required to maintain an 8 mmol/l glucose concentration during …