PE Cockram, M Kist, S Prakash, SH Chen… - Cell Death & …, 2021 - nature.com
The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …
JZ Roberts, N Crawford, DB Longley - Cell Death & Differentiation, 2022 - nature.com
Cell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially harmful cells from within an organism, such as cells with damaged DNA that could lead to …
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases) maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
L Lu, X Zhai, X Li, S Wang, L Zhang, L Wang… - Nature …, 2022 - nature.com
Abstract Linear (Met1-linked) ubiquitination is involved inflammatory and innate immune signaling. Previous studies have characterized enzymes regulating the addition and …
Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid …
R Yau, M Rape - Nature cell biology, 2016 - nature.com
Ubiquitylation is essential for signal transduction as well as cell division and differentiation in all eukaryotes. Substrate modifications range from a single ubiquitin molecule to complex …
Protein ubiquitination is one of the most powerful posttranslational modifications of proteins, as it regulates a plethora of cellular processes in distinct manners. Simple …
M Akutsu, I Dikic, A Bremm - Journal of cell science, 2016 - journals.biologists.com
Ubiquitin plays an essential role in modulating protein functions, and deregulation of the ubiquitin system leads to the development of multiple human diseases. Owing to its …
E Oh, D Akopian, M Rape - Annual review of cell and …, 2018 - annualreviews.org
Ubiquitylation is an essential posttranslational modification that controls cell division, differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …