The protein corona from nanomedicine to environmental science

M Mahmoudi, MP Landry, A Moore… - Nature Reviews Materials, 2023 - nature.com
The protein corona spontaneously develops and evolves on the surface of nanoscale
materials when they are exposed to biological environments, altering their physiochemical …

Obstacles and opportunities in a forward vision for cancer nanomedicine

I de Lázaro, DJ Mooney - Nature materials, 2021 - nature.com
Cancer nanomedicines were initially envisioned as magic bullets, travelling through the
circulation to target tumours while sparing healthy tissues the toxicity of classic …

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

EÁ Tóth, L Turiák, T Visnovitz, C Cserép… - Journal of …, 2021 - Wiley Online Library
In this study we tested whether a protein corona is formed around extracellular vesicles
(EVs) in blood plasma. We isolated medium‐sized nascent EVs of THP1 cells as well as of …

Hard and soft protein corona of nanomaterials: Analysis and relevance

R García-Álvarez, M Vallet-Regí - Nanomaterials, 2021 - mdpi.com
Upon contact with a biological milieu, nanomaterials tend to interact with biomolecules
present in the media, especially proteins, leading to the formation of the so-called “protein …

An overview of nanoparticle protein corona literature

MJ Hajipour, R Safavi‐Sohi, S Sharifi, N Mahmoud… - Small, 2023 - Wiley Online Library
The protein corona forms spontaneously on nanoparticle surfaces when nanomaterials are
introduced into any biological system/fluid. Reliable characterization of the protein corona is …

Current hurdles to the translation of nanomedicines from bench to the clinic

S Đorđević, MM Gonzalez, I Conejos-Sánchez… - Drug delivery and …, 2022 - Springer
The field of nanomedicine has significantly influenced research areas such as drug delivery,
diagnostics, theranostics, and regenerative medicine; however, the further development of …

Nanotools for sepsis diagnosis and treatment

L Papafilippou, A Claxton, P Dark… - Advanced …, 2021 - Wiley Online Library
Sepsis is one of the leading causes of death worldwide with high mortality rates and a
pathological complexity hindering early and accurate diagnosis. Today, laboratory culture …

Nano-omics: nanotechnology-based multidimensional harvesting of the blood-circulating cancerome

L Gardner, K Kostarelos, P Mallick, C Dive… - Nature Reviews …, 2022 - nature.com
Over the past decade, the development of 'simple'blood tests that enable cancer screening,
diagnosis or monitoring and facilitate the design of personalized therapies without the need …

Person-specific biomolecular coronas modulate nanoparticle interactions with immune cells in human blood

Y Ju, HG Kelly, LF Dagley, A Reynaldi, TE Schlub… - ACS …, 2020 - ACS Publications
When nanoparticles interact with human blood, a multitude of plasma components adsorb
onto the surface of the nanoparticles, forming a biomolecular corona. Corona composition is …

[HTML][HTML] Point-of-care diagnostics for sepsis using clinical biomarkers and microfluidic technology

Z Bradley, N Bhalla - Biosensors and Bioelectronics, 2023 - Elsevier
Sepsis is a life-threatening immune response which is caused by a wide variety of sources
and is a leading cause of mortality globally. Rapid diagnosis and appropriate antibiotic …