Cryptococcus neoformans is a common environmental saprophyte and human fungal
pathogen that primarily causes disease in immunocompromised individuals. Similar to many …

Cryptococcus is an invasive fungus that seriously endangers human life and health, with a
complex and well-established immune-escaping mechanism that interferes with the function …

Human cancer cells operate a variety of effective molecular and signaling mechanisms
which allow them to escape host immune surveillance and thus progress the disease. We …

In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate
signaling pathway is critical for virulence. We recently demonstrated the key role of the …

With their distinctive flavor, fragrance, and nutritional value, strawberry (Fragaria× ananassa
Duch.) fruits are popular worldwide. However, strawberry is susceptible to pathogenic fungi …

Inositol tris/tetrakis phosphate kinases (IP3-4K) in the human fungal priority pathogens,
Cryptococcus neoformans (Cn Arg1) and Candida albicans (Ca Ipk2), convey numerous …

Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …

New antifungals with unique modes of action are urgently needed to treat the increasing
global burden of invasive fungal infections. The fungal inositol polyphosphate kinase (IPK) …

Inositol polyphosphates (IPs) and inositol pyrophosphates (PP–IPs) regulate diverse cellular
processes in eukaryotic cells. IPs and PP–IPs are highly negatively charged and exert their …

Monocytes are considered to play a central role in the pathogenesis of Cryptococcus
neoformans infection. Monocytes and monocyte-derived macrophages and dendritic cells …