Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-
differentiation, undergo epigenetic, epithelial-mesenchymal, immunological and metabolic …

Cellular homeostasis and adaptation to various environmental conditions are importantly
regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling …

INTRODUCTION Genome-sequencing efforts over the past decade have profiled the genetic
landscape of thousands of tumors and solidified the concept of cancer as a highly …

Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the
WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell …

WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the
maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present …

In human cells, cytoplasmic dynein-1 is essential for long-distance transport of many cargos,
including organelles, RNAs, proteins, and viruses, towards microtubule minus ends. To …

The Wnt signaling pathway is a highly conserved system that regulates complex biological
processes across all metazoan species. At the cellular level, secreted Wnt proteins serve to …

Chemotherapy resistance is the major cause of nasopharyngeal carcinoma (NPC) treatment
failure. Tripartite motif-containing protein (TRIM) family members play important roles in …

G-protein-coupled receptors (GPCRs) mediate neuromodulation through the activation of
heterotrimeric G proteins (Gαβγ). Classical models depict that G protein activation leads to a …