Antibiotic resistance mechanisms in M. tuberculosis: an update

L Nguyen - Archives of toxicology, 2016 - Springer
Abstract Treatment of tuberculosis (TB) has been a therapeutic challenge because of not
only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also …

Molecular Biology of Drug Resistance in Mycobacterium tuberculosis

T Smith, KA Wolff, L Nguyen - … tuberculosis and its Interaction with the …, 2012 - Springer
Tuberculosis (TB) has become a curable disease, thanks to the discovery of antibiotics.
However, it has remained one of the most difficult infections to treat. Most current TB …

[HTML][HTML] Molecular mechanism of bacterial persistence by HipA

E Germain, D Castro-Roa, N Zenkin, K Gerdes - Molecular cell, 2013 - cell.com
HipA of Escherichia coli is a eukaryote-like serine-threonine kinase that inhibits cell growth
and induces persistence (multidrug tolerance). Previously, it was proposed that HipA inhibits …

Toxins-antitoxins: diversity, evolution and function

F Hayes, L Van Melderen - Critical reviews in biochemistry and …, 2011 - Taylor & Francis
Genes for toxin-antitoxin (TA) complexes are widespread in prokaryote genomes, and
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …

[HTML][HTML] Quantitative susceptibility mapping to evaluate the early stage of Alzheimer's disease

HG Kim, S Park, HY Rhee, KM Lee, CW Ryu… - NeuroImage: Clinical, 2017 - Elsevier
The objective of this study was to evaluate susceptibility changes caused by iron
accumulation in cognitive normal (CN) elderly, those with amnestic mild cognitive …

MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs

P Tiwari, G Arora, M Singh, S Kidwai… - Nature …, 2015 - nature.com
Toxin–antitoxin (TA) systems are highly conserved in members of the Mycobacterium
tuberculosis (Mtb) complex and have been proposed to play an important role in physiology …

Toxin-antitoxin systems in clinical pathogens

L Fernández-García, L Blasco, M Lopez, G Bou… - Toxins, 2016 - mdpi.com
Toxin-antitoxin (TA) systems are prevalent in bacteria and archaea. Although not essential
for normal cell growth, TA systems are implicated in multiple cellular functions associated …

Emerging roles of toxin-antitoxin modules in bacterial pathogenesis

B Kędzierska, F Hayes - Molecules, 2016 - mdpi.com
Toxin-antitoxin (TA) cassettes are encoded widely by bacteria. The modules typically
comprise a protein toxin and protein or RNA antitoxin that sequesters the toxin factor. Toxin …

Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site

JM Schifano, R Edifor, JD Sharp… - Proceedings of the …, 2013 - National Acad Sciences
The Mycobacterium tuberculosis genome contains an unusually high number of toxin–
antitoxin modules, some of which have been suggested to play a role in the establishment …

Are bacterial persisters dormant cells only?

J Zou, B Peng, J Qu, J Zheng - Frontiers in Microbiology, 2022 - frontiersin.org
Bacterial persisters are a sub-population of phenotypic variants that tolerate high
concentrations of antibiotics within the genetically homogeneous cells. They resume division …