Antibiotic resistance mechanisms in M. tuberculosis: an update
L Nguyen - Archives of toxicology, 2016 - Springer
Abstract Treatment of tuberculosis (TB) has been a therapeutic challenge because of not
only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also …
only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also …
Molecular Biology of Drug Resistance in Mycobacterium tuberculosis
T Smith, KA Wolff, L Nguyen - … tuberculosis and its Interaction with the …, 2012 - Springer
Tuberculosis (TB) has become a curable disease, thanks to the discovery of antibiotics.
However, it has remained one of the most difficult infections to treat. Most current TB …
However, it has remained one of the most difficult infections to treat. Most current TB …
[HTML][HTML] Molecular mechanism of bacterial persistence by HipA
E Germain, D Castro-Roa, N Zenkin, K Gerdes - Molecular cell, 2013 - cell.com
HipA of Escherichia coli is a eukaryote-like serine-threonine kinase that inhibits cell growth
and induces persistence (multidrug tolerance). Previously, it was proposed that HipA inhibits …
and induces persistence (multidrug tolerance). Previously, it was proposed that HipA inhibits …
Toxins-antitoxins: diversity, evolution and function
F Hayes, L Van Melderen - Critical reviews in biochemistry and …, 2011 - Taylor & Francis
Genes for toxin-antitoxin (TA) complexes are widespread in prokaryote genomes, and
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …
[HTML][HTML] Quantitative susceptibility mapping to evaluate the early stage of Alzheimer's disease
The objective of this study was to evaluate susceptibility changes caused by iron
accumulation in cognitive normal (CN) elderly, those with amnestic mild cognitive …
accumulation in cognitive normal (CN) elderly, those with amnestic mild cognitive …
MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs
Toxin–antitoxin (TA) systems are highly conserved in members of the Mycobacterium
tuberculosis (Mtb) complex and have been proposed to play an important role in physiology …
tuberculosis (Mtb) complex and have been proposed to play an important role in physiology …
Toxin-antitoxin systems in clinical pathogens
Toxin-antitoxin (TA) systems are prevalent in bacteria and archaea. Although not essential
for normal cell growth, TA systems are implicated in multiple cellular functions associated …
for normal cell growth, TA systems are implicated in multiple cellular functions associated …
Emerging roles of toxin-antitoxin modules in bacterial pathogenesis
B Kędzierska, F Hayes - Molecules, 2016 - mdpi.com
Toxin-antitoxin (TA) cassettes are encoded widely by bacteria. The modules typically
comprise a protein toxin and protein or RNA antitoxin that sequesters the toxin factor. Toxin …
comprise a protein toxin and protein or RNA antitoxin that sequesters the toxin factor. Toxin …
Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site
JM Schifano, R Edifor, JD Sharp… - Proceedings of the …, 2013 - National Acad Sciences
The Mycobacterium tuberculosis genome contains an unusually high number of toxin–
antitoxin modules, some of which have been suggested to play a role in the establishment …
antitoxin modules, some of which have been suggested to play a role in the establishment …
Are bacterial persisters dormant cells only?
J Zou, B Peng, J Qu, J Zheng - Frontiers in Microbiology, 2022 - frontiersin.org
Bacterial persisters are a sub-population of phenotypic variants that tolerate high
concentrations of antibiotics within the genetically homogeneous cells. They resume division …
concentrations of antibiotics within the genetically homogeneous cells. They resume division …