The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Background: Recent reports suggested the involvement of oxidative stress-and endoplasmic
reticulum stress (ERS)-associated pathways in the progression of ischemia/reperfusion (I/R) …

Retinitis pigmentosa is the most common form of hereditary retinal degeneration causing
blindness. Great progress has been made in the identification of the causative genes. Gene …

The endoplasmic reticulum (ER) is the primary intracellular organelle responsible for protein
and lipid biosynthesis, protein folding and trafficking, calcium homeostasis, and several …

Glaucoma is the leading cause of irreversible blindness worldwide, and the burden of the
disease continues to grow as the global population ages. Currently, the only treatment …

Dihydroquercetin (DHQ), a dihydroxyflavone, possesses potent antioxidant properties and is
proposed to be useful in the prevention and treatment of cardiovascular disease. In this …

Background Retinitis pigmentosa (RP) is an inherited human retinal disorder that causes
progressive photoreceptor cell loss, leading to severe vision impairment or blindness …

Diabetes-associated visual cycle impairment has been implicated in diabetic retinopathy,
and chronic hyperglycemia causes detrimental effects on visual function. Chrysin, a naturally …

The autosomal dominant form of retinitis pigmentosa (adRP) is a blindness-causing
conformational disease largely linked to mutations of rhodopsin. Molecular simulations …