Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the
elderly individuals. Clinically, patients initially present with short-term memory loss …

New neurons incorporate into the granular cell layer of the dentate gyrus throughout life.
Neurogenesis is modulated by behavior and plays a major role in hippocampal plasticity …

Alzheimer's disease-associated β-amyloid peptides (Aβ) are generated by the sequential
proteolytic processing of amyloid precursor protein (APP) by β-and γ-secretases. There is …

Background Alzheimer's disease (AD) involves increased accumulation of amyloid-β (Aβ)
plaques and neurofibrillary tangles as well as neuronal loss in various regions of the …

Summary Adaptor protein 4 (AP-4) is the most recently discovered and least well-
characterized member of the family of heterotetrameric adaptor protein (AP) complexes that …

γ-Secretase is a promiscuous protease that cleaves bitopic membrane proteins within the
lipid bilayer. Elucidating both the mechanistic basis of γ-secretase proteolysis and the …

Zinc, an essential micronutrient for life, was first discovered in 1869 and later found to be
indispensable for the normal development of plants and for the normal growth of rats and …

One of the characteristic hallmarks of Alzheimer's disease (AD) is an accumulation of
amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the …

Membrane proteins are constantly being trafficked in cells and the relevant proteins in
Alzheimer's disease (AD), such as the amyloid precursor protein (APP) and its processing …