Rewiring urea cycle metabolism in cancer to support anabolism
Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the
anabolic synthesis of macromolecules that are required during tumour proliferation and …
anabolic synthesis of macromolecules that are required during tumour proliferation and …
The context-specific roles of urea cycle enzymes in tumorigenesis
The expression of the urea cycle (UC) proteins is dysregulated in multiple cancers, providing
metabolic benefits to tumor survival, proliferation, and growth. Here, we review the main …
metabolic benefits to tumor survival, proliferation, and growth. Here, we review the main …
Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with
no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small …
no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small …
Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity
Hematological and solid cancers catabolize the semiessential amino acid arginine to drive
cell proliferation. However, the resulting low arginine microenvironment also impairs …
cell proliferation. However, the resulting low arginine microenvironment also impairs …
Arginase as a potential biomarker of disease progression: a molecular imaging perspective
G S. Clemente, A van Waarde, I F. Antunes… - International Journal of …, 2020 - mdpi.com
Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …
Polymer-drug conjugates: Design principles, emerging synthetic strategies and clinical overview
Adagen, an enzyme replacement treatment for adenosine deaminase deficiency, was the
first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval …
first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval …
The importance of cellular metabolic pathways in pathogenesis and selective treatments of hematological malignancies
Despite recent advancements in the treatment of hematologic malignancies and the
emergence of newer and more sophisticated therapeutic approaches such as …
emergence of newer and more sophisticated therapeutic approaches such as …
Mesenchymal stromal cells (MSCs): an ally of B-cell acute lymphoblastic leukemia (B-ALL) cells in disease maintenance and progression within the bone marrow …
Simple Summary B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric
cancer. Even though the cure rate actually exceeds 85%, the prognosis of …
cancer. Even though the cure rate actually exceeds 85%, the prognosis of …
Metabolic reprogramming in hematologic malignancies: advances and clinical perspectives
Z Yu, X Zhou, X Wang - Cancer Research, 2022 - AACR
Metabolic reprogramming is a hallmark of cancer progression. Metabolic activity supports
tumorigenesis and tumor progression, allowing cells to uptake essential nutrients from the …
tumorigenesis and tumor progression, allowing cells to uptake essential nutrients from the …
Current outlook on autophagy in human leukemia: foe in cancer stem cells and drug resistance, friend in new therapeutic interventions
Autophagy is an evolutionarily conserved cellular recycling process in cell homeostasis and
stress adaptation. It confers protection and promotes survival in response to metabolic …
stress adaptation. It confers protection and promotes survival in response to metabolic …