As the whole world is epidemically aging, the burden of periodontitis and tooth loss is
becoming a major health concern. Growing meta-epidemiological data implicate chronic …

The senescence-associated secretory phenotype (SASP), which accumulates over the
course of normal aging and in age-related diseases, is a crucial driver of chronic …

Background Assessing the biocompatibility of materials is crucial for ensuring the safety and
well-being of patients by preventing undesirable, toxic, immune, or allergic reactions, and …

Accelerated cellular senescence may be a crucial process for periodontitis progression
because it integrates the damaging effects of major periodontitis risk factors. Cellular …

The recent identification of senescent cells in periodontal tissues has the potential to provide
new insights into the underlying mechanisms of periodontal disease etiology. DNA damage …

In periodontitis, gingival fibroblasts (GFs) interact with and respond to oral pathogens,
significantly contributing to perpetuation of chronic inflammation and tissue destruction. The …

The prevalence of periodontitis increases with physiological aging. However, whether
bacteria associated with periodontal diseases foster aging and the mechanisms by which …

Background Periodontal disease is a chronic inflammatory disease caused by
periodontopathic bacteria accumulated in the gingival sulcus and periodontal pocket …

Abstract Background and Objectives Ageing is associated with an impaired cellular function
that can affect tissue architecture and wound healing in gingival and periodontal tissues …

Interactions between gingival fibroblasts (GFs) and oral pathogens contribute to the
chronicity of inflammation in periodontitis. Epigenetic changes in DNA methylation are …