BACKGROUND The locus coeruleus (LC) is the primary source of norepinephrine in the
brain and regulates arousal and sleep. Animal research shows that it plays important roles …

Altered predictive coding may underlie the reduced auditory mismatch negativity amplitude
observed in patients with dementia. We hypothesized that accumulating dementia …

Neuropsychiatric symptoms (NPS) have been associated with a risk of accelerated cognitive
decline or conversion to dementia of the Alzheimer's Disease (AD) type. Moreover, the NPS …

Objectives Healthy age-related cognitive changes are highly heterogeneous across
individuals. This variability is increasingly explained through the lens of spontaneous …

Abstract Study Objectives The ability to generate slow waves (SW) during non-rapid eye
movement (NREM) sleep decreases as early as the 5th decade of life, predominantly over …

The locus coeruleus (LC) is the primary source of norepinephrine (NE) in the brain, and the
LC-NE system is involved in regulating arousal and sleep. It plays key roles in the transition …

Objective Animal studies established that the locus coeruleus (LC) plays important roles in
sleep and wakefulness regulation. Whether it contributes to sleep variability in humans is not …

Alzheimer's disease (AD) is a biological, clinical continuum that covers the preclinical,
prodromal, and clinical phases of the disease. Early diagnosis and identification of the …