The isolated anatomical position and blood-labyrinth barrier hampers systemic drug delivery
to the mammalian inner ear. Intratympanic placement of drugs and permeation via the round …

There are multiple etiologies and phenotypes of age-related hearing loss or presbyacusis. In
this review we summarize findings from animal and human studies of presbyacusis …

Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost,
leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals …

The cochlear implant (CI) is widely considered to be one of the most innovative and
successful neuroprosthetic treatments developed to date. Although outcomes vary, CIs are …

Macroautophagy/autophagy dysfunction is associated with many neurodegenerative
diseases. TFEB (transcription factor EB), an important molecule that regulates lysosomal …

Loss of primary neuronal inputs inevitably strikes every neural circuit. The deafferented
circuit could propagate, amplify, or mitigate input loss, thus affecting the circuit's output. How …

Noise exposure is one of the most common causes of hearing loss and peripheral damage
to the auditory system. A growing literature suggests that the auditory system can …

Tinnitus alters auditory–somatosensory plasticity in the cochlear nucleus (CN).
Correspondingly, bimodal auditory–somatosensory stimulation treatment attenuates tinnitus …

Although the application of human embryonic stem cells (hESCs) in stem cell–replacement
therapy remains promising, its potential is hindered by a low cell survival rate in post …

Hearing loss is associated with cognitive decline and dementia risk. Sensorineural hearing
loss suppresses hippocampal neurogenesis, resulting in cognitive decline. However, the …