As of 2017, the World Health Organization has made the recognition, prevention, and
management of sepsis a global health priority. 1 Hippocrates considered the term a …

Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …

Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents
to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A …

Background Acute kidney injury (AKI) in the intensive care unit is associated with significant
mortality and morbidity. Objectives To determine and update previous recommendations for …

Acute kidney injury (AKI) is a widespread problem of epidemic status. Compelling evidence
indicates that the incidence of AKI is rapidly increasing, particularly among hospitalized …

Introduction There is no consensus definition of acute renal failure (ARF) in critically ill
patients. More than 30 different definitions have been used in the literature, creating much …

ContextAlthough acute renal failure (ARF) is believed to be common in the setting of critical
illness and is associated with a high risk of death, little is known about its epidemiology and …

BACKGROUND: Acute kidney injury (AKI) is common in hospitalized patients. The impact of
AKI on long-term outcomes is controversial. STUDY DESIGN: Systematic review and meta …

Background The optimal intensity of renal-replacement therapy in critically ill patients with
acute kidney injury is controversial. Methods We randomly assigned critically ill patients with …

Introduction The lack of a standard definition for acute kidney injury has resulted in a large
variation in the reported incidence and associated mortality. RIFLE, a newly developed …