Progression of the role of CRYAB in signaling pathways and cancers

JF Zhang, J Liu, JL Wu, WF Li, ZW Chen… - OncoTargets and …, 2019 - Taylor & Francis
CRYAB is a member of the small heat shock protein family, first discovered in the lens of the
eye, and involved in various diseases, such as eye and heart diseases and even cancers …

[HTML][HTML] The multifaceted nature of αB-crystallin

J Hayashi, JA Carver - Cell Stress and Chaperones, 2020 - Elsevier
In vivo, small heat-shock proteins (sHsps) are key players in maintaining a healthy
proteome. αB-crystallin (αB-c) or HspB5 is one of the most widespread and populous of the …

Small heat shock proteins in cancers: Functions and therapeutic potential for cancer therapy

J Xiong, Y Li, X Tan, L Fu - International journal of molecular sciences, 2020 - mdpi.com
Small heat shock proteins (sHSPs) are ubiquitous ATP-independent chaperones that play
essential roles in response to cellular stresses and protein homeostasis. Investigations of …

Comprehensive transcriptomic analysis of heat shock proteins in the molecular subtypes of human breast cancer

FCM Zoppino, ME Guerrero-Gimenez, GN Castro… - BMC cancer, 2018 - Springer
Abstract Background Heat Shock Proteins (HSPs), a family of genes with key roles in
proteostasis, have been extensively associated with cancer behaviour. However, the HSP …

Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell carcinoma

XP Tu, QH Qiu, LS Chen, XN Luo, ZM Lu, SY Zhang… - BMC cancer, 2015 - Springer
Background Neutrophil-lymphocyte ratio (NLR) has been shown to be associated with
prognosis in various solid tumors. This study aimed to evaluate the prognostic role of NLR in …

Preoperative neutrophil-to-lymphocyte ratio predicts long-term survival in patients undergoing total laryngectomy with advanced laryngeal squamous cell carcinoma: a …

Y Fu, W Liu, D OuYang, A Yang, Q Zhang - Medicine, 2016 - journals.lww.com
There is increasing evidence that the neutrophil-to-lymphocyte ratio (NLR) is a stage-
independent predictor of poor outcome in patients with cancer. The purpose of this study …

αB-crystallin: Portrait of a malignant chaperone as a cancer therapeutic target

D Malin, V Petrovic, E Strekalova, B Sharma… - Pharmacology & …, 2016 - Elsevier
Abstract αB-crystallin is a widely expressed member of the small heat shock protein family
that protects cells from stress by its dual function as a molecular chaperone to preserve …

The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells

OF Karatas, I Suer, B Yuceturk, M Yilmaz, Y Hajiyev… - Tumor Biology, 2016 - Springer
The cancer stem-like cells (CSLCs) are tumorigenic cells promoting initiation, progression,
and spread of the tumor. Accumulating evidences suggested the presence of CSLCs in …

Mi R‐221 as a pre‐and postoperative plasma biomarker for larynx cancer patients

SS Yilmaz, E Guzel, OF Karatas, M Yilmaz… - The …, 2015 - Wiley Online Library
Objective In order to identify a plasma microRNA (miRNA) signature of larynx cancer (LCa),
we examined miRNAs profile of plasma samples obtained from 30 LCa patients …

αB-crystallin as a promising target in pathological conditions-a review

M Maksymiuk, A Sabiborowicz, A Tuzimek… - Annals of Agricultural …, 2020 - agro.icm.edu.pl
Introduction and objective. αB-crystallin belongs to the ubiquitous family of small heat-shock
proteins. It was discovered as a physiological protein of the eye lens, maintaining its liquid …