The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

Cancer is a disease associated with genomic instability that often results from oncogene
activation. This in turn leads to hyperproliferation and replication stress. However, the …

Recent experiments have demonstrated that the Polycomb group (PcG) gene EZH2 is highly
expressed in metastatic prostate cancer and in lymphomas. EZH2 is a component of the …

The role of the myc gene family in the biology of normal and cancer cells has been
intensively studied since the early 1980s. myc genes, responding to diverse external and …

Deregulated expression of c-MYC occurs in a broad range of human cancers and is often
associated with poor prognosis, indicating a key role for this oncogene in tumour …

Myc genes are key regulators of cell proliferation, and their deregulation contributes to the
genesis of most human tumours. Recently, a wealth of data has shed new light on the …

As its role in tumor progression emerges, the PI3K/PKB (Akt) pathway presents an appealing
cancer therapeutic target. Recent studies have investigated the mechanisms underlying the …

Apoptosis and proliferation are intimately coupled. Some cell cycle regulators can influence
both cell division and programmed cell death. The linkage of cell cycle and apoptosis has …

To address the role of N-myc in neurogenesis and in nervous system tumors, it was
conditionally disrupted in neuronal progenitor cells (NPCs) with a nestin-Cre transgene. Null …