In this review we describe the influence of modified nucleobases in order to understand the
changes they introduce in double and triple helix forming oligomers with the aim to study …

The genome and its nucleotide precursor pool are under sustained attack by radiation,
reactive oxygen and nitrogen species, chemical carcinogens, hydrolytic reactions, and …

Mackiewicz & Norris LLP 57 ABSTRACT This invention is directed to novel purine-based
compounds for inclusion into oligonucleotides. The compounds of the invention, when …

The synthesis of modified oligonucleotides by the phosphoramidite approach and their
applications - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …

The rapid growth of biotechnology has triggered an increasing demand for modified
oligonucleotides dedicated mostly to diagnostic and therapeutic applications. The plethoric …

To appreciate the nature of this subject, it is useful to first consider the general topic of
chemical carcinogenesis. In a sense the field began with the observations of two London …

Stille Coupling is a versatile C–C bond forming reaction with high functional group tolerance
under mild conditions. Our on column synthesis concept for RNA modification is based on …

Improved methodology has been developed for preparation of oligodeoxynucleotides
bearing adducts on the N 2 position of guanine in which the adduction reaction is carried out …

Palladium-catalyzed CN bond-formation is rapidly becoming a staple in the organic
synthesis repertoire, and modern developments in the catalysis field have led to highly …

In the Suzuki arylations of unprotected halonucleosides in aqueous media, 8-bromo-2 '-
deoxyguanosine (8BrdG) couplings were slower to reach completion than the …