Abstract Stromal interaction molecule (STIM)-1 and-2 are multi-domain, single-pass
transmembrane proteins involved in sensing changes in compartmentalized calcium (Ca 2+) …

Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating,
storage, and transport mechanisms are required to maintain normal cellular physiology …

Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and
aggregated forms are associated with synucleinopathies including Parkinson's disease …

Mediated through the combined action of STIM proteins and Orai channels, store-operated
Ca 2+ entry (SOCE) functions ubiquitously among different cell types. The existence of …

Decreased luminal endoplasmic reticulum (ER) Ca2+ concentration triggers oligomerization
and clustering of the ER Ca2+ sensor STIM1 to promote its association with plasma …

STIM1 has been identified as a new warm sensor, but the exact molecular mechanism
remains unclear. In this study, a variety of mutants of STIM1, Orai1 and Orai3 were …

Considerable progress has been made elucidating the molecular mechanisms of calcium
(Ca 2+) sensing by stromal interaction molecules (STIMs) and the basis for Orai channel …

Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating,
storage, and transport mechanisms are required to maintain normal cellular physiology …

Ca2+ is a ubiquitous intracellular messenger. It regulates a variety of cellular activities,
ranging from muscle contraction, neuronal transmission, secretion and cell growth to …

Considerable progress has been made elucidating the molecular mechanisms of calcium
(Ca2+) sensing by stromal interaction molecules (STIMs) and the basis for Orai channel …