Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Marine secondary metabolites are a promising source of unexploited drugs that have a wide
structural diversity and have shown a variety of biological activities. These compounds are …

The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this
review, following the format used in the 1998–2008 reviews of this series. The …

Covering: 2009. Previous review: Nat. Prod. Rep., 2010, 27, 165 This review covers the
literature published in 2009 for marine natural products, with 857 citations (588 for the …

Highly dynamic mitotic spindle microtubules are superb therapeutic targets for a group of
chemically diverse and clinically successful anticancer drugs. Microtubule-targeted drugs …

Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical
molecules. So far, a large number of macrocyclic natural products have been isolated and …

Tubulin tyrosine ligase (TTL) catalyzes the post-translational retyrosination of detyrosinated
α-tubulin. Despite the indispensable role of TTL in cell and organism development, its …

The microtubule (MT) associated protein tau, which is highly expressed in the axons of
neurons, is an endogenous MT-stabilizing agent that plays an important role in axonal …

Microtubules are polar cytoskeletal filaments assembled from head-to-tail and comprised of
lateral associations of α/β-tubulin heterodimers that play key role in various cellular …

Covering: late 2008 to August 2013 Nature has yielded numerous classes of chemically
distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel …