Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

H Döhner, E Estey, D Grimwade… - Blood, The Journal …, 2017 - ashpublications.org
The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and
management of acute myeloid leukemia (AML) in adults, published in 2010, has found …

Treatment of older adults with FLT3-mutated AML: Emerging paradigms and the role of frontline FLT3 inhibitors

NJ Short, D Nguyen, F Ravandi - Blood cancer journal, 2023 - nature.com
FLT3 is the most frequently mutated gene in acute myeloid leukemia (AML), with FLT3
internal tandem duplication (ITD) mutations being associated with a more aggressive clinical …

Venetoclax-based therapies for acute myeloid leukemia

VA Guerra, C DiNardo, M Konopleva - Best practice & research Clinical …, 2019 - Elsevier
The prognosis of adult acute myeloid leukemia (AML) remains poor, with the long-term
survival rate less than 50%. However, the current paradigms of treatment are changing …

Tolerability and efficacy of the anticluster of differentiation 47 antibody magrolimab combined with azacitidine in patients with previously untreated AML: phase Ib …

NG Daver, P Vyas, S Kambhampati… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE Magrolimab is a first-in-class humanized monoclonal antibody against cluster of
differentiation 47, an antiphagocytic signal used by cancer cells to evade phagocytosis …

Clinical applications of nanomedicine in cancer therapy

M Norouzi, M Amerian, M Amerian, F Atyabi - Drug discovery today, 2020 - Elsevier
Cancer incidence and mortality are rapidly growing worldwide. In attempts to develop more
efficacious therapeutic regimens for patients with cancer, nanomedicines have found …

Genomic landscape in acute myeloid leukemia and its implications in risk classification and targeted therapies

HA Hou, HF Tien - Journal of biomedical science, 2020 - Springer
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy in terms of
clinical features, underlying pathogenesis and treatment outcomes. Recent advances in …

Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study …

G Nagel, D Weber, E Fromm, S Erhardt, M Lübbert… - Annals of …, 2017 - Springer
We describe genetic and clinical characteristics of acute myeloid leukemia (AML) patients
according to age from an academic population-based registry. Adult patients with newly …

Additional gene mutations may refine the 2017 European LeukemiaNet classification in adult patients with de novo acute myeloid leukemia aged< 60 years

AK Eisfeld, J Kohlschmidt, A Mims, D Nicolet… - Leukemia, 2020 - nature.com
Abstract The European LeukemiaNet (ELN) recommendations for diagnosis and
management of acute myeloid leukemia (AML) have become an important tool to assess …

Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care

H Döhner, A Dolnik, L Tang, JF Seymour, MD Minden… - Leukemia, 2018 - nature.com
Older patients with newly diagnosed acute myeloid leukemia (AML) in the phase 3 AZA-AML-
001 study were evaluated at entry for cytogenetic abnormalities, and a subgroup of patients …

Long-term survival after intensive chemotherapy or hypomethylating agents in AML patients aged 70 years and older: a large patient data set study from European …

C Récher, C Röllig, E Bérard, S Bertoli, PY Dumas… - Leukemia, 2022 - nature.com
The outcome of acute myeloid leukemia patients aged 70 years or older is poor. Defining the
best treatment option remains controversial especially when choosing between intensive …