Domains have been identified in the Gag proteins of a number of retroviruses, and in the
matrix proteins of the rhabdoviruses and filoviruses, that play a critical role in the pinching off …

Abstract Human immunodeficiency virus 1 (HIV-1) and other retroviruses synthesize a DNA
copy of their genome after entry into the host cell. Integration of this DNA into the host cell's …

The replication of human immunodeficiency virus type 1 (HIV-1) in nondividing host cells
such as those of macrophage lineage is an important feature of AIDS pathogenesis. The …

The human immunodeficiency virus type 1 (HIV-1) Gag protein precursor, Pr55Gag, contains
at its C-terminal end a proline-rich, 6-kDa domain designated p6. Two functions have been …

Viral protein R (Vpr) encoded by HIV-1 is a facultative inducer of apoptosis. When added to
intact cells or purified mitochondria, micromolar and submicromolar doses of synthetic Vpr …

Replication of human immunodeficiency virus type 1 (HIV‐1) in non‐dividing cells critically
depends on import of the viral pre‐integration complex into the nucleus. Genetic evidence …

Cyclophilin A (CyPA) is incorporated into human immunodeficiency virus type 1 (HIV-1)
virions via contact with the Gag polyprotein. Genetic or pharmacologic disruption of CyPA …

HIV-1 Vpr promotes nuclear entry of viral nucleic acids in nondividing macrophages and
also causes a G2 cell-cycle arrest. Consistent with its role in nuclear transport, we show Vpr …

Human immunodeficiency virus type 1 (HIV-1) is a retrovirus that can cause extensive
cytopathicity in T cells. However, long-term productive infection of T-cell lines has been …

Human immunodeficiency virus type 1 (HIV-1) vpr inhibits the replication of tumor cell lines
and peripheral blood mononuclear cells. Here it is demonstrated that expression of vpr …