Nrf2/Keap1/ARE signaling: Towards specific regulation
The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …
defense against oxidative stress, the hallmark of numerous diseases such as …
Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke
Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain,
which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there …
which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there …
[HTML][HTML] Nrf2-Keap1 signaling in oxidative and reductive stress
I Bellezza, I Giambanco, A Minelli, R Donato - Biochimica et Biophysica …, 2018 - Elsevier
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved
intracellular defense mechanism to counteract oxidative stress. Sequestered by cytoplasmic …
intracellular defense mechanism to counteract oxidative stress. Sequestered by cytoplasmic …
Transcriptional regulation by Nrf2
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
[HTML][HTML] NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches
Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …
defense mechanisms as well as physiological functions, and intracellular signaling …
A rational design of metal–organic framework nanozyme with high-performance copper active centers for alleviating chemical corneal burns
Y Tang, Y Han, J Zhao, Y Lv, C Fan, L Zheng… - Nano-Micro Letters, 2023 - Springer
Metal–organic frameworks (MOFs) have attracted significant research interest in biomimetic
catalysis. However, the modulation of the activity of MOFs by precisely tuning the …
catalysis. However, the modulation of the activity of MOFs by precisely tuning the …
[HTML][HTML] The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases
Oxidative stress is defined as an imbalance between production of free radicals and reactive
metabolites or [reactive oxygen species (ROS)] and their elimination by through protective …
metabolites or [reactive oxygen species (ROS)] and their elimination by through protective …
Targeting mutant p53 for efficient cancer therapy
VJN Bykov, SE Eriksson, J Bianchi… - Nature Reviews Cancer, 2018 - nature.com
The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type
p53 can suppress tumour development by multiple pathways. However, mutation of TP53 …
p53 can suppress tumour development by multiple pathways. However, mutation of TP53 …
Molecular mechanism of cellular oxidative stress sensing by Keap1
T Suzuki, A Muramatsu, R Saito, T Iso, T Shibata… - Cell reports, 2019 - cell.com
Summary The Keap1-Nrf2 system plays a central role in the oxidative stress response;
however, the identity of the reactive oxygen species sensor within Keap1 remains poorly …
however, the identity of the reactive oxygen species sensor within Keap1 remains poorly …
[HTML][HTML] Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
YK Mahmoud, HMA Abdelrazek - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Recently, there is growing interest in the natural bioactive components having anticancer
activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa) …
activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa) …