With the discovery of endothelial progenitor cells (EPCs) in the late 1990s, a paradigm shift
in the concept of neoangiogenesis occurred. The identification of circulating EPCs in …

Angiotensin II type 1 receptor antagonists (ARBs) have become an important drug class in
the treatment of hypertension and heart failure and the protection from diabetic nephropathy …

Vitamin D, besides having an essential role in calcium and bone metabolism, also acts as a
mediator of many non-calcemic effects through modulations of several biological responses …

Vascular endothelial dysfunction is regarded as a primary phenotypic expression of normal
human aging. This senescence-induced disorder is the likely culprit underlying the …

Endothelial dysfunction has been associated with the development of atherosclerosis and
cardiovascular diseases. Adult endothelial progenitor cells (EPCs) are derived from …

Hypertension is the single most important risk factor for cardiovascular disease and, thus,
remains a global public health challenge. Significant progress has been made during the …

The peroxisome proliferator-activated receptors (PPARs) and the retinoid X receptors
(RXRs) are ligand-activated transcription factors that coordinately regulate gene expression …

Diabetes induces a decrease in the number and function of different pro-angiogenic cell
types generically designated as putative endothelial progenitor cells (EPC), which …

Extensive injury of endothelial cells in blood vasculature, especially in the microcirculatory
system, frequently occurs in hosts suffering from sepsis and the accompanied systemic …

Endothelial progenitor cells (EPC s), which can be cultured in vitro from mononuclear cells
in peripheral blood or bone marrow, express both hematopoietic stem cell and endothelial …