Spirocyclic frameworks have attracted synthetic practitioners due to their unique three-
dimensional assembly, improved metabolic stability, solubility, and increased molecular …

Isatin is an important building block in organic synthesis. The electron‐deficient carbonyl in
C‐3 site is similar to aldehyde. C‐3 carbonyl is also able to function as the O‐nucleophile …

A fluorinative Beckmann fragmentation of α-oximinoamides was devised to provide
synthetically useful carbamoyl fluorides. High selectivity for fragmentation over a potentially …

N-fused pyrrolidinyl spirooxindole belongs to a class of privileged heterocyclic scaffolds and
is prevalent in natural alkaloids and synthetic pharmaceutical molecules. To realize the …

Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat to human
health and well-being and put a persistent strain on the health care system. Development of …

The additive-free [3+ 2] annulation from isatins, amino acids with 2-styrylbenzoxazoles, was
described, providing a series of functional and structurally complex 3, 3′-pyrrolidinyl …

An unexpected isomerization of azomethine ylides generated in situ from isatin with indoline-
2-carboxylic acid has been disclosed, providing direct access to N-functionalized indole …

In recent years, vinyl selenones were rediscovered as useful building blocks for new
synthetic transformations. This review will highlight these advances in the field of multiple …

Multicomponent reactions (MCRs) have emerged as powerful tools in synthetic chemistry for
the efficient synthesis of diverse molecular scaffolds, particularly nitrogen‐containing …

1, 3-Dipolar cycloaddition is one of the important chemical reactions between a 1, 3-dipole
and a dipolarophile to construct a five-membered heterocyclic compound. As an available α …