Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

Platelets are small anucleate cell fragments that circulate in blood playing crucial role in
managing vascular integrity and regulating hemostasis. Platelets are also involved in the …

When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

Platelets in a thrombus interact with (anti) coagulation factors and support blood
coagulation. In the concept of cell‐based control of coagulation, three different roles of …

Phosphatidylserine (PtdSer) exposure on the surface of activated platelets requires the
action of a phospholipid scramblase (s), and serves as a scaffold for the assembly of the …

Rupture of a vulnerable atherosclerotic plaque causes thrombus formation and precipitates
cardiovascular diseases. In addition to the thrombogenic content of a plaque, also the …

Current understanding of how platelets localize coagulation to wound sites has come mainly
from studies of a subpopulation of activated platelets. In this review, we summarize data from …

Traditionally, in vitro flow chamber experiments and in vivo arterial thrombosis studies have
been proved to be of vital importance to elucidate the mechanisms of platelet thrombus …

As platelets aggregate and activate at the site of vascular injury to stem bleeding, they are
subjected to a myriad of biochemical and biophysical signals and cues. As clot formation …

Platelet aggregation is a critical event in thrombus formation and thus has extensive
involvement in physiological and pathological processes. The aggregation response …