The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine
kinase, which senses and integrates several intracellular and environmental cues to …

Age‐related cognitive failure is a main devastating incident affecting even healthy people.
Alzheimer's disease (AD) is the utmost common form of dementia among the geriatric …

Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple
species. We have recently shown that DR in progeroid DNA repair‐deficient mice …

Brain somatic mutations confer genomic diversity in the human brain and cause
neurodevelopmental disorders. Recently, brain somatic activating mutations in MTOR have …

Autism spectrum disorder (ASD) is highly prevalent in subjects with Tuberous Sclerosis
Complex (TSC), but we are not still able to reliably predict which infants will develop ASD …

Leigh syndrome is a fatal neurometabolic disorder caused by defects in mitochondrial
function. Mechanistic target of rapamycin (mTOR) inhibition with rapamycin attenuates …

Cerebrovascular dysfunction is detected prior to the onset of cognitive and histopathological
changes in Alzheimer's disease (AD). Increasing evidence indicates a critical role of …

Tuberous sclerosis complex (TSC) is a rare genetic disease of autosomal dominant
transmission that, in most cases, results from the presence of pathogenic variants of the …

Autism Spectrum Conditions (ASC) are a group of neurodevelopmental disorders
characterized by deficits in social communication and interaction as well as repetitive …

Autism spectrum disorder (ASD) has become a common neurodevelopmental disorder. The
heterogeneity of ASD poses great challenges for its research and clinical translation. On the …