Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

In the past 65 years, antifolates targeting folate metabolism played a pivotal role in drug
treatment of malignant, microbial, parasitic and chronic inflammatory diseases. Drug …

Until recently, the transport of folates into cells and across epithelia has been interpreted
primarily within the context of two transporters with high affinity and specificity for folates, the …

Members of the family of B9 vitamins are commonly known as folates. They are derived
entirely from dietary sources and are key one-carbon donors required for de novo nucleotide …

Antifolates, folate analogs that inhibit vitamin B9 (folic acid)-using cellular enzymes, have
been used over several decades for the treatment of cancer and inflammatory diseases …

This review attempts to provide a comprehensive overview of the biology of the
physiologically and pharmacologically important transport system termed the “reduced folate …

This review summarizes the biology of the proton-coupled folate transporter (PCFT). PCFT
was identified in 2006 as the primary transporter for intestinal absorption of dietary folates …

The properties of intestinal folate absorption were documented decades ago. However, it
was only recently that the proton-coupled folate transporter (PCFT) was identified and its …

The folate pathway plays a crucial role in the regeneration and repair of the adult CNS after
injury. Here, we have shown in rodents that such repair occurs at least in part through DNA …

This laboratory recently identified a human gene that encodes a novel folate transporter
[Homo sapiens proton-coupled folate transporter (Hs PCFT); SLC46A1] required for …