The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on
helper factors to replicate. Those helper factors can be provided by coinfecting helper …

Adeno-associated virus (AAV) based vectors have emerged as important tools for gene
therapy in humans. The recent successes seen in Phase I/II clinical trials have also …

Abstract The Adeno-associated viruses (AAVs) are not associated with any diseases, and
their ability to package non-genomic DNA and to transduce different cell/tissue populations …

Adeno-associated virus (AAV) was first discovered as a contaminant of adenovirus stocks in
the 1960s. The development of recombinant AAV vectors (rAAV) was facilitated by early …

Herpes simplex virus type 1 (HSV-1) DNA replication is associated with nuclear domains
called ND10, which contain host recombination proteins such as RPA, RAD51, and NBS1 …

The APOBEC3 proteins form a multigene family of cytidine deaminases with inhibitory
activity against viruses and retrotransposons. In contrast to APOBEC3G (A3G), APOBEC3A …

Adeno-associated virus (AAV) belongs to the Dependoparvovirus genus of the Parvoviridae
family. AAV replication relies on a helper virus, such as adenovirus (Ad). Co-infection of AAV …

DNA viruses that replicate in the nucleus encompass a range of ubiquitous and clinically
important viruses, from acute pathogens to persistent tumor viruses. These viruses must co …

Recombinant adeno-associated virus has emerged as one of the most promising gene
therapy delivery vectors. Development of these vectors took advantage of key features of the …

Virus infections have dramatic effects on structural and morphological characteristics of the
host cell. The gene product of open reading frame 3 in the early region 4 (E4orf3) of …