Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends …

Y Zhou, J Wang, Z Gu, S Wang, W Zhu… - Chemical …, 2016 - ACS Publications
Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Estrogens and androgens in skeletal physiology and pathophysiology

M Almeida, MR Laurent, V Dubois… - Physiological …, 2017 - journals.physiology.org
Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …

Sarcopenia: etiology, clinical consequences, intervention, and assessment

T Lang, T Streeper, P Cawthon, K Baldwin… - Osteoporosis …, 2010 - Springer
The aging process is associated with loss of muscle mass and strength and decline in
physical functioning. The term sarcopenia is primarily defined as low level of muscle mass …

Development of selective androgen receptor modulators (SARMs)

R Narayanan, CC Coss, JT Dalton - Molecular and cellular endocrinology, 2018 - Elsevier
Abstract The Androgen Receptor (AR), a member of the steroid hormone receptor family,
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …

Impact of nutrition on muscle mass, strength, and performance in older adults

A Mithal, JP Bonjour, S Boonen, P Burckhardt… - Osteoporosis …, 2013 - Springer
Muscle strength plays an important role in determining risk for falls, which result in fractures
and other injuries. While bone loss has long been recognized as an inevitable consequence …

Protective actions of sex steroid hormones in Alzheimer's disease

CJ Pike, JC Carroll, ER Rosario, AM Barron - Frontiers in …, 2009 - Elsevier
Risk for Alzheimer's disease (AD) is associated with age-related loss of sex steroid
hormones in both women and men. In post-menopausal women, the precipitous depletion of …

[HTML][HTML] Selective androgen receptor modulators: the future of androgen therapy?

AR Christiansen, LI Lipshultz, JM Hotaling… - Translational …, 2020 - ncbi.nlm.nih.gov
Selective androgen receptor modulators (SARMs) are small molecule drugs that function as
either androgen receptor (AR) agonists or antagonists. Variability in AR regulatory proteins …

[HTML][HTML] Sex hormones, aging, and Alzheimer's disease

AM Barron, CJ Pike - Frontiers in bioscience (Elite edition), 2012 - ncbi.nlm.nih.gov
A promising strategy to delay and perhaps prevent Alzheimer's disease (AD) is to identify the
age-related changes that put the brain at risk for the disease. A significant normal age …

Drug insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging

S Bhasin, OM Calof, TW Storer, ML Lee… - Nature clinical practice …, 2006 - nature.com
Several regulatory concerns have hindered development of androgens as anabolic
therapies, despite unequivocal evidence that testosterone supplementation increases …

Selective androgen receptor modulators as function promoting therapies

S Bhasin, R Jasuja - Current Opinion in Clinical Nutrition & …, 2009 - journals.lww.com
Selective androgen receptor modulators as function promoting... : Current Opinion in Clinical
Nutrition & Metabolic Care Selective androgen receptor modulators as function promoting …