Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

Cells release adenosine triphosphate (ATP), which activates plasma membrane–localized
P2X and P2Y receptors and thereby modulates cellular function in an autocrine or paracrine …

The purinergic signalling system, which uses purines and pyrimidines as chemical
transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development …

P2X7 is an intriguing ionotropic receptor for which the activation by extracellular ATP
induces rapid inward cationic currents and intracellular signalling pathways associated with …

Under nonpathological conditions, the extracellular nucleotide concentration remains
constant and low (nM range) because of a close balance between ATP release and ATP …

There is long-term (trophic) purinergic signalling involving cell proliferation, differentiation,
motility and death in the development and regeneration of most systems of the body, in …

Ion channels have been shown to be involved in oncogenesis and efforts are being poured
in to target the ion channels. There are many clinically approved drugs with ion channels as …

Abstract Adenosine 5′-triphosphate (ATP) is found in high concentrations in the
extracellular microenvironment of tumours and is postulated to play critical roles in cancer …

There are multiple roles for purinergic signalling in both male and female reproductive
organs. ATP, released as a cotransmitter with noradrenaline from sympathetic nerves …