Asthma is a common chronic inflammatory condition of the airways that affects about 350
million people globally. In 5%–10% of individuals, it is severe, with considerable morbidity …

Airway mucus is a hydrogel with unique biophysical properties due to its primary water
composition and a small proportion of large anionic glycoproteins or mucins. The …

Background Mucus plugs in asthmatic airways are associated with airway obstruction and
the activity of inflammatory cytokines, specifically interleukin (IL)-5 and IL-13, and they may …

Background Microvascular abnormalities and impaired gas transfer have been observed in
patients with COVID-19. The progression of pulmonary changes in these patients remains …

Mucus provides a protective barrier that is crucial for host defense in the lungs. However,
excessive or abnormal mucus can have pathophysiological consequences in many …

Asthma is one of the most common chronic respiratory diseases, affecting over 300 million
people worldwide [1]. It is defined by intermittent bronchospasms that cause symptoms such …

Airway remodeling (AR) with chronic inflammation, are key features in asthma pathogenesis.
AR characterized by structural changes in the bronchial wall is associated with a specific …

Eosinophilic inflammation is primarily characterized by type 2 immune responses against
parasitic organisms. In the contemporary human being especially in developed countries …

Introduction The hallmark of most patients with severe asthma is type 2 inflammation, driven
by innate and adaptive immune responses leading to either allergic or non-allergic …

Asthma is a chronic respiratory disease marked by heterogeneity and variable clinical
outcomes. Recent therapeutic advances have highlighted patients achieving optimal …